tachipirina 1000 INTERACTIONS
The intake of probenecid inhibits the binding of paracetamol to glucuronic acid, resulting in a reduction in the clearance of paracetamol approximately twofold. In patients taking probenecid concomitantly, the dose of paracetamol should be reduced. The metabolism of paracetamol is increased in patients taking enzyme-inducing drugs, such as rifampicin and some antiepileptics (carbamazepine, phenytoin, phenobarbital, primidone). Some isolated reports describe unexpected hepatotoxicity in patients taking enzyme-inducing medicinal products.
Concomitant administration of paracetamol and AZT (zidovudine) increases the tendency to neutropenia. Therefore, co-administration of this drug together with AZT should only take place on the advice of your doctor. Concomitant intake of drugs that accelerate gastric emptying, such as metoclopramide, accelerates the absorption and onset of action of paracetamol. The concomitant use of drugs that slow gastric emptying can delay the absorption and onset of action of paracetamol. Cholestyramine reduces the absorption of paracetamol and, therefore, cannot be administered before one hour has passed after administration of paracetamol. buy Tachipirina 1000 online
Repeated intake of paracetamol for periods longer than one week increases the effect of anticoagulants, in particular warfarin. Therefore, long-term administration of paracetamol in patients treated with anticoagulants should only take place under medical supervision. Occasional intake of paracetamol has no significant effect on bleeding tendency. Caution should be exercised when paracetamol is used concomitantly with flucloxacillin as concomitant use has been associated with high anion gap metabolic acidosis, especially in patients with risk factors (see section 4.4).
Effects on laboratory tests: paracetamol can interfere with uric acid determinations that use phosphotungstic acid and with blood glucose determinations that use the glucose-oxidase-peroxidase reaction. Probenecid causes an almost two-fold reduction in the clearance of paracetamol by inhibiting its conjugation with glucuronic acid. A reduction in paracetamol should be considered in case of concomitant treatment with probenecid. Paracetamol increases plasma levels of acetylsalicylic acid and chloramphenicol.
Analgesics and antipyretics, anilides.
Store in the original packaging to protect the medicine from light and humidity.
Hypersensitivity to the active ingredient or to any of the excipients listed in paragraph 6.1; severe renal failure; alcohol abuse.
TACHIPIRINA OROSOLUBILE 1000 MG GRANULES
EXCIPIENTS Tachipirina 1000
Sorbitol, talc, basic butyl methacrylate copolymer, hypromellose, heavy magnesium oxide, stearic acid, sodium carmellose, sodium lauryl sulphate, titanium dioxide (E 171), sucralose, magnesium stearate (Ph.Eur.), simethicone, cappuccino flavor (contains maltodextrin , gum arabic (E414), natural and/or natural-identical flavoring substances, triacetin (E1518), N,2,3-trimethyl-2-(propan-2-yl) butanamide). buy Tachipirina 1000 online
Tachipirina 1000 SIDE EFFECTS
The MedDRA system organ classification is used with the following frequencies: very common (>= 1/10); common (>= 1/100, < 1/10); uncommon (>= 1/1,000, < 1/100); rare (>= 1/10,000, < 1/1,000); very rare(<1/10,000). Pathologies of the blood and lymphatic system. Rare: anemia, non-haemolytic anemias and spinal cord depression; thrombocytopenia. Vascular pathologies. Rare: edema. Gastrointestinal disorders. Rare: exocrine pancreatic conditions, acute and chronic pancreatitis, gastrointestinal haemorrhages, abdominal pain, diarrhoea, nausea, vomiting. buy Tachipirina 1000 online
Hepatobiliary disorders. Rare: hepatic failure, hepatic necrosis, jaundice. Immune system disorders. Rare: allergic conditions, anaphylactic reaction, allergies to foods, food additives, drugs and other chemicals. Pathologies of the skin and subcutaneous tissue. Rare: urticaria, pruritus, rash, sweating, purpura, angioedema; very rare: very rare cases of serious skin reactions have been reported. Renal and urinary disorders. Rare: nephropathy, nephropathy and tubular disorders. Very rare cases of serious skin reactions have been reported. buy Tachipirina 1000 online
Nephrotoxic effects are infrequent and have not been reported in association with therapeutic doses, except after prolonged administration. Reporting of suspected adverse reactions. Reporting suspected adverse reactions that occur after authorization of the medicine is important, as it allows continuous monitoring of the benefit/risk balance of the medicine. buy Tachipirina 1000 online
Tachipirina 1000 MG WARNINGS
To avoid the risk of overdose, it is necessary to check that any other drugs taken concurrently do not contain paracetamol. Paracetamol should be administered with caution to patients with mild to moderate hepatocellular insufficiency (including Gilbert’s syndrome), severe hepatic insufficiency (Child-Pugh >9), acute hepatitis, in concomitant treatment with drugs that alter liver function, glucose-6-phosphate dehydrogenase, haemolytic anemia, chronic alcohol abuse, severe renal failure (creatinine clearance < 10 ml/min. buy Tachipirina 1000 online[see section 4.2]). In the presence of high fever or signs of secondary infection or if symptoms persist for more than 3 days, you should consult your doctor. In general, Medicines containing paracetamol can only be taken for a few days and in low doses without consulting your doctor or dentist. In case of prolonged incorrect use of analgesics at high doses, headache episodes may occur which should not be treated with higher doses of the drug. In general, the habitual intake of analgesics, especially a combination of different analgesic substances, can cause permanent renal damage with the risk of renal failure (analgesic nephropathy). Prolonged or frequent use is not recommended. buy Tachipirina 1000 online
Patients should be advised not to take other products containing paracetamol at the same time. Taking multiple daily doses in a single administration can seriously damage the liver. Then, the patient does not lose consciousness, however a doctor should be consulted immediately. Prolonged use without medical supervision may be harmful. In children treated with 60 mg/kg per day of paracetamol, the association with another antipyretic is not justified except in cases of ineffectiveness. Sudden cessation of taking analgesics after a prolonged period of incorrect use at high doses can cause headache, fatigue, muscle pain, nervousness and autonomic symptoms. buy Tachipirina 1000 online
These withdrawal symptoms resolve within a few days. Until that time, further intake of painkillers should be avoided and should not be resumed without consulting your doctor. Caution should be exercised if paracetamol is taken in association with CYP3A4 inducers or the use of substances that induce hepatic enzymes such as rifampicin, cimetidine and antiepileptics such as glutethimide, phenobarbital and carbamazepine. Caution should be exercised when administering paracetamol to patients with renal insufficiency (creatinine clearance <= 30 ml/min., see section 4.2). Consumption of alcohol should be avoided during treatment with paracetamol. buy Tachipirina 1000 online
The risks of overdose are greater in patients with non-cirrhotic alcoholic liver disease. Caution should be exercised in case of chronic alcoholism. In patients with alcohol abuse the dose should be reduced (see section 4.2). In this case, the daily dose should not exceed 2 grams. Caution is advised if paracetamol is administered concomitantly with flucloxacillin due to the increased risk of high anion gap metabolic acidosis (HAGMA), particularly in patients with severe renal impairment, sepsis, malnutrition and other sources of glutathione deficiency (e.g. alcoholism chronic), as well as in those using maximum daily doses of paracetamol. Careful monitoring, including measurement of urinary 5-oxoproline, is recommended.
Tachipirina orosoluble contains: sorbitol: this medicine contains 805.80 mg of sorbitol per sachet. Patients with hereditary fructose intolerance should not be given this medicine; The additive effect of co-administration of medicinal products containing sorbitol (or fructose) and daily dietary intake of sorbitol (or fructose) should be considered. buy Tachipirina 1000 online
The sorbitol content in medicinal products for oral use may modify the bioavailability of other co-administered medicinal products for oral use; sodium: this medicinal product contains less than 1 mmol (23 mg) sodium per sachet, i.e. “essentially sodium-free”. In the presence of high fever or signs of secondary infection or persistence of symptoms beyond 3 days, a re-evaluation of the treatment should be carried out. Doses higher than recommended imply the risk of very serious liver injury. Treatment with the antidote should be administered as soon as possible (see section 4.9). Paracetamol should be used with caution in cases of dehydration and chronic malnutrition.
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